Genetic models of Parkinson disease
نویسندگان
چکیده
منابع مشابه
Genetic heterogeneity in Parkinson disease
Neurology 2012;79:619–620 Parkinson disease (PD) is considered a sporadic neurodegenerative disorder, though genetic factors are frequently involved in its etiology. That some familial presentations of PD have been associated with different mutated genes suggests that some genetic variants can also modulate the risk for “nonfamilial” presentation of PD. The hypothesis-free genomewide associatio...
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In this review I outline the arguments as to whether we should consider Parkinson disease one or more than one entity and discuss genetic findings from Mendelian and whole-genome association analysis in that context. I discuss what the demonstration of disease spread implies for our analysis of the genetic and epidemiologic risk factors for disease and outline the surprising fact that we now ha...
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The history of the Wolff-Parkinson-White (WPW) syndrome is a 50-year–long tale of speculation and discussion among physiologists, anatomists, and clinicians about how to explain the frequently occurring tachycardias in patients showing a strange ECG.1 That riddle was solved in 1967 in Amsterdam when Durrer and associates2 showed that the WPW syndrome was based on a second connection between the...
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Alzheimer's disease (AD) is the most common form of neurodegenerative disorders. Memory loss in an alert person and impairment in the function of language, attention, perception, judgment or problem solving can occur in patients with AD. However, there are some medications in order to delay the debilitating aspects of the disease; but unfortunately, scientists could not found approaches to cure...
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The microtubule-associated protein tau (MAPT) region has been conceptualized as a model of the interaction between genetics and functional disease outcomes in neurodegenerative disorders, such as Parkinson disease (PD). Indeed, haplotype-specific differences in expression and alternative splicing of MAPT transcripts affect cellular functions at different levels, increasing susceptibility to a r...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2009
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2008.10.005